{"id":954,"date":"2026-01-09T10:48:27","date_gmt":"2026-01-09T16:48:27","guid":{"rendered":"https:\/\/centroneurologicointegralguatemala.com.gt\/centro-neurologico-integral-guatemala\/?p=954"},"modified":"2026-01-09T10:48:28","modified_gmt":"2026-01-09T16:48:28","slug":"logran-que-celulas-madre-aprendan-a-volver-a-conectar-el-cerebro-tras-un-acv","status":"publish","type":"post","link":"https:\/\/centroneurologicointegralguatemala.com.gt\/centro-neurologico-integral-guatemala\/index.php\/2026\/01\/09\/logran-que-celulas-madre-aprendan-a-volver-a-conectar-el-cerebro-tras-un-acv\/","title":{"rendered":"Logran que c\u00e9lulas madre aprendan a volver a conectar el cerebro tras un ACV"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

Cada a\u00f1o, el ataque cerebrovascular afecta a m\u00e1s de 15 millones de personas en todo el mundo y representa una de las principales causas de discapacidad y muerte (Imagen Ilustrativa Infobae)<\/p>\n\n\n\n

Un equipo de investigadores de los Estados Unidos y Singapur dise\u00f1\u00f3 un m\u00e9todo para que restablezcan funciones perdidas tras lesiones graves. Cu\u00e1les fueron los resultados del experimento en ratones.<\/p>\n\n\n\n

A diferencia de tejidos como la c\u00f3rnea, capaces de repararse r\u00e1pidamente, el cerebro <\/strong><\/a>adulto permanece estable ante la lesi\u00f3n<\/strong> y muestra escaso potencial regenerativo, salvo en situaciones de trauma o enfermedad.<\/p>\n\n\n\n

Esta limitaci\u00f3n llev\u00f3 a investigadores de los Estados Unidos y Singapur a explorar nuevas v\u00edas para la reparaci\u00f3n <\/strong>cerebral<\/strong><\/a>.<\/strong><\/p>\n\n\n\n

Consiguieron que las c\u00e9lulas madre trasplantadas sobrevivieran en zonas cerebrales da\u00f1adas y se transformaran en neuronas <\/strong>capaces de reconectar circuitos interrumpidos. Esto demuestra que ser\u00eda posible restaurar la conectividad neuronal tras el ACV.<\/p>\n\n\n\n

Obst\u00e1culos en la regeneraci\u00f3n cerebral<\/h2>\n\n\n\n

El principal obst\u00e1culo es el ambiente hostil que enfrenta cualquier intento de terapia regenerativa en el cerebro da\u00f1ado.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Las c\u00e9lulas madre trasplantadas logran sobrevivir en zonas cerebrales da\u00f1adas y se transforman en neuronas capaces de reconectar circuitos interrumpidos (Imagen Ilustrativa Infobae)<\/p>\n\n\n\n

\u201cEn el cerebro adulto, tras un ataque cerebrovascular, se forma un quiste,<\/strong> una cavidad llena de todo tipo de mol\u00e9culas inflamatorias, as\u00ed que es como si las c\u00e9lulas terap\u00e9uticas estuviesen en un pantano peligroso lleno de amenazas\u201d, dijo Su-Chun Zhang<\/strong>, director del Centro para Enfermedades Neurol\u00f3gicas en el Instituto de Descubrimientos M\u00e9dicos Sanford Burnham Prebys y uno de los autores del estudio.<\/p>\n\n\n\n

Adem\u00e1s, la presencia de tejido cicatricial refuerza este entorno adverso: \u201cEl tejido cicatricial rodea la cavidad para proteger el cerebro de m\u00e1s da\u00f1o, pero tambi\u00e9n crea una barrera contra cualquier regeneraci\u00f3n potencial\u201d, a\u00f1adi\u00f3 Zhang.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Estas dificultades impulsaron estrategias alternativas, como injertar nuevas c\u00e9lulas cerca de la regi\u00f3n da\u00f1ada, con el objetivo de restablecer los circuitos mediante un rodeo.<\/p>\n\n\n\n

Para Zhang, ese abordaje resulta insuficiente: \u201cTras un ACV, la lesi\u00f3n suele ser muy grande y presenta un reto inmenso para los esfuerzos de reconectar funcionalmente el cerebro con el tronco cerebral y la m\u00e9dula espinal\u201d.<\/p>\n\n\n\n

Descubrimientos sobre la orientaci\u00f3n neuronal<\/h2>\n\n\n\n

Reconstrucciones tridimensionales de estas neuronas demostraron que los patrones de proyecciones espinosas, esenciales para la conectividad del sistema nervioso, coinciden con los que presentan las neuronas normales entre la corteza cerebral y la m\u00e9dula espinal.<\/p>\n\n\n\n

Para analizar la capacidad de orientaci\u00f3n de las neuronas regeneradas, el equipo emple\u00f3 c\u00f3digos gen\u00e9ticos de rastreo, integrados con secuenciaci\u00f3n de perfiles de expresi\u00f3n g\u00e9nica.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Reconstrucciones 3D demuestran que los patrones de proyecci\u00f3n neuronal regenerados reproducen la conectividad normal entre corteza cerebral y m\u00e9dula espinal. (Imagen Ilustrativa Infobae)<\/p>\n\n\n\n

Zhang puntualiz\u00f3: \u201cRevelamos que cada tipo celular tiene su propio c\u00f3digo y, una vez que se convierten en neuronas, ese c\u00f3digo les indica enviar sus proyecciones o axones a distintas partes del cerebro y la m\u00e9dula espinal\u201d.<\/p>\n\n\n\n

Zhang describi\u00f3 el alcance de este hallazgo: \u201cEs la primera vez que se reporta este fen\u00f3meno tan llamativo y es importante porque b\u00e1sicamente nos dice que, si contamos con los tipos adecuados de c\u00e9lulas trasplantadas, ellas ya saben a d\u00f3nde ir y qu\u00e9 hacer para reparar lo perdido\u201d.<\/p>\n\n\n\n

La investigaci\u00f3n, respaldada por el Consejo Nacional de Investigaci\u00f3n M\u00e9dica de Singapur<\/strong> y la Escuela M\u00e9dica de la Universidad de Duke<\/strong>, utiliz\u00f3 aprendizaje autom\u00e1tico para identificar cuatro subtipos neuronales derivados de las c\u00e9lulas trasplantadas, cada uno con patrones singulares de expresi\u00f3n g\u00e9nica responsables de guiar la extensi\u00f3n de los axones.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

El uso de aprendizaje autom\u00e1tico permiti\u00f3 identificar cuatro subtipos neuronales, cada uno guiado por c\u00f3digos g\u00e9nicos responsables de dirigir las conexiones axonales (Imagen Ilustrativa Infobae)<\/p>\n\n\n\n

El impacto funcional depende, adem\u00e1s, de factores de transcripci\u00f3n que controlan esos patrones gen\u00e9ticos. Al eliminar un factor conocido como Ctip2 de las c\u00e9lulas madre, observaron que las proyecciones axonales cambiaban por completo, con un aumento de axones hacia el hipocampo y la am\u00edgdala.<\/p>\n\n\n\n

Zhang resumi\u00f3 la relevancia cl\u00ednica de estos avances: \u201cSi aprendemos m\u00e1s sobre estos subtipos de neuronas trasplantadas, podr\u00edamos predecir sus proyecciones y conectividad para seleccionar los tipos neuronales apropiados en la reconstrucci\u00f3n dirigida de circuitos en pacientes\u201d.<\/p>\n\n\n\n

A\u00f1adi\u00f3: \u201cEsto abre un futuro prometedor para la terapia celular en beneficio de millones de personas que sufren accidentes cerebrovasculares y otras enfermedades neurol\u00f3gicas devastadoras\u201d.<\/p>\n\n\n\n

Compartir nota:<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Cada a\u00f1o, el ataque cerebrovascular afecta a m\u00e1s de 15 millones de personas en todo el mundo y representa una de las principales causas de discapacidad y muerte (Imagen Ilustrativa Infobae) Un equipo de investigadores de los Estados Unidos y Singapur dise\u00f1\u00f3 un m\u00e9todo para que restablezcan funciones perdidas tras lesiones graves. Cu\u00e1les fueron los … <\/p>\n

Continuar leyendo “Logran que c\u00e9lulas madre aprendan a volver a conectar el cerebro tras un ACV”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":955,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-954","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categoria"],"yoast_head":"\nLogran que c\u00e9lulas madre aprendan a volver a conectar el cerebro tras un ACV - Centro Neurologico Integral de Guatemala<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/centroneurologicointegralguatemala.com.gt\/centro-neurologico-integral-guatemala\/index.php\/2026\/01\/09\/logran-que-celulas-madre-aprendan-a-volver-a-conectar-el-cerebro-tras-un-acv\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Logran que c\u00e9lulas madre aprendan a volver a conectar el cerebro tras un ACV - Centro Neurologico Integral de Guatemala\" \/>\n<meta property=\"og:description\" content=\"Cada a\u00f1o, el ataque cerebrovascular afecta a m\u00e1s de 15 millones de personas en todo el mundo y representa una de las principales causas de discapacidad y muerte (Imagen Ilustrativa Infobae) Un equipo de investigadores de los Estados Unidos y Singapur dise\u00f1\u00f3 un m\u00e9todo para que restablezcan funciones perdidas tras lesiones graves. 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